學(xué)位：博士研究生

職稱：副教授

研究領(lǐng)域：衛(wèi)生統(tǒng)計(jì)學(xué)、生物信息學(xué)、流式細(xì)胞術(shù)

郵箱：kwang_shzu@163.com

通訊地址：石河子大學(xué)醫(yī)學(xué)院杏1樓辦公室717號(hào)

科研學(xué)術(shù)工作經(jīng)歷與教育背景：

2014.09-至今，石河子大學(xué)醫(yī)學(xué)院，預(yù)防醫(yī)學(xué)系，副教授

2013.10-2014.08, 生物信息分析公司（墨爾本），生物信息學(xué)，數(shù)據(jù)分析師

2007.01-2013.09，昆士蘭大學(xué)物理學(xué)院數(shù)學(xué)系，博士后

2006.01-2006.06, 香港城市大學(xué)管理科學(xué)系，博士后

2005.04-2005.12, 昆士蘭大學(xué)，物理學(xué)院數(shù)學(xué)系，研究官員

2002.08-2005.03,Curtin大學(xué)，副研究員

2000.06-2001.03, 香港城市大學(xué)，管理科學(xué)系，研究助理

1999.09-2000.02, 科廷大學(xué)，公共衛(wèi)生學(xué)院，流行病學(xué)與生物統(tǒng)計(jì)學(xué)系，訪問(wèn)學(xué)者

1994.05-2006.09，中國(guó)工程物理研究院，工程師

1988.08-1994.04，新疆八一農(nóng)學(xué)院，數(shù)學(xué)教研室，助教

1999.09-2002.08，科廷大學(xué),公共衛(wèi)生學(xué)院，流行病學(xué)與生物統(tǒng)計(jì)學(xué)系，博士

1990.09-1993.07，北京大學(xué)，概率統(tǒng)計(jì)系，碩士

1984.09-1988.07，北京大學(xué)，數(shù)學(xué)系，學(xué)士

科研項(xiàng)目：

1.兵團(tuán)創(chuàng)新創(chuàng)業(yè)平臺(tái)與基地建設(shè)計(jì)劃項(xiàng)目：國(guó)家血液病臨床研究中心分中心（2021CA002），主要完成人，在研。

2.兵團(tuán)重點(diǎn)領(lǐng)域科技攻關(guān)項(xiàng)目：兵團(tuán)重大突發(fā)疫情精準(zhǔn)防控決策支持平臺(tái)研發(fā)與示范應(yīng)用，（2021AB034），主要完成人，在研。

3.國(guó)家自然科學(xué)基金地區(qū)項(xiàng)目：用于急性白血病篩查和免疫分型的八色流式細(xì)胞術(shù)及其數(shù)據(jù)分析，（81860374），主持，結(jié)題。

4.國(guó)家自然科學(xué)基金地區(qū)項(xiàng)目：新疆哈薩克族代謝綜合征及其各因子對(duì)心腦血管病危險(xiǎn)性預(yù)測(cè)的隊(duì)列研究（81560551），主要完成人，結(jié)題。

5.Telethon New Children's Hospital Research Fund，Are genome-wide DNA methylation profiles associated with asthma and allergy in children exposed to a 'western' environment? 2013/01-2015/12，主要完成人，結(jié)題。

6.Telethon New Children's Hospital Research Fund，Genome-wide DNA methylation profiling in children with acute asthma and HRV-C infection，2013/01 -2014/12，主要完成人，結(jié)題。

7.Australian Research Council (ARC)，Joint clustering and matching of multivariate samples across objects，2012/01-2014/12，主要完成人，結(jié)題。

8.Griffith Health Institute，Comorbidity and multimorbidity patterns of mental health conditions，2010/01-2010/12，主要完成人，結(jié)題。

9.UQ Early Career Researcher (ECR) Grant，The mixture of Skew t-distribution and its application to FACS data，2008/01-2009/12，主持，結(jié)題。

10.Australian Research Council（ARC），Mixture models for high-dimensional clustering with applications to brain tumour classification, network intrusion and text classi-fication，2008/01-2010/12，主要完成人，結(jié)題。

11.Australian Research Council（ARC），Multivariate methods for the analysis of microarray gene-expression data with applications to cancer diagnostics，2007/01-2011/12，主要完成人，結(jié)題。

12.Competitive Earmarked Research Grant (CERG), Research Grants Council of Hong Kong，On the mixing of failure time distributions for non-standard survival data analysis: theory and applications，2004/01-2007/12，主要完成人，結(jié)題。

13.WA Health Promotion Foundation，Physical Activity for Sedentary Seniors，2003/01-2005/12，主要完成人，結(jié)題。

14.National Health & Medical Research Council (NHMRC) ，Hierarchical finite mixture modelling of health outcomes: a risk-adjusted random effects approach，2003/01-2004/12，主要完成人，結(jié)題。

15.City University Strategic Research Grant, Hong Kong，Modeling zero-inflated serial count data with correlated random effects，2002/01-2004/12，主要完成人，結(jié)題。

16.Research Grants Council of Hong Kong，Finite mixture survival models with random effects: a GLMM approach，1999/01-2001/12，主要完成人，結(jié)題。

學(xué)術(shù)論文：

1.Wang, Kui*. Clustering of time-course gene expression profiles using normal mixture models with autoregressive random effects,BMC Bioinformatics, 2012,13:300.

2.Wang, Kui*. Multivariate skewt mixture models: applications to fluorescence-activated cell sorting data, DICTA 2009 (Conference of Digital Image Computing: Techniques and Applications, Melbourne), 526-531, 2009.

3.Wang, Kui*. Two-component Poisson mixture regression modelling of count data with bivariate random effects, Mathematical and Computer Modelling, 2007, 46：1468-1476.

4.Wang, Kui*. Multilevel survival modelling of recurrent urinary tract infections, Computer Methods and Programs in Biomedicine, 2007,87(3):225-229.

5.Wang, Kui*. Multilevel logistic regression modelling with correlated random effects: application to the Smoking Cessation for Youth study，Statistics in Medicine, 2006,25(22):3864-3876.

6.Wang, Kui*. Factors influencing hospitalisation of infants for recurrent gastroenteritis in western Australia, Methods of Information in Medicine, 2003,42(3):251-254.

7.Wang, Kui*. A bivariate zero-inflated Poisson regres-sion model to analyze occupational injurie. Accid Anal Prev, 2003,35(4):625-629.

8.Wang, Kui*. A hierarchical Poisson mixture regression model to analyse maternity length of hospital stay, Statistics in Medicine, 2002,21(23):3639-3654.

9.Wang, Kui*. A zero-inflated Poisson mixed model to analyze diagnosis related groups with majority of same-day hospital stays, Computer Methods and Programs in Biomedicine, 2002,68(3):195-203.

10.郭玉娟;等;王奎*.急性髓系白血病流式細(xì)胞術(shù)全程自動(dòng)化診斷技術(shù)研究，石河子大學(xué)學(xué)報(bào)(自然科學(xué)版)，2022,40(4): 17-23.北大中文核心期刊.

11.雷偉,等,王奎*.人工神經(jīng)網(wǎng)絡(luò)在流式細(xì)胞術(shù)數(shù)據(jù)分析中的應(yīng)用，醫(yī)學(xué)信息．

12.農(nóng)衛(wèi)霞,王奎*. miR-20a-5p表達(dá)對(duì)胃粘膜相關(guān)組織淋巴瘤增殖的影響及其機(jī)制研究，石河子大學(xué)學(xué)報(bào)(自然科學(xué)版),2021,39(01):102-108.北大中文核心期刊.

13.農(nóng)衛(wèi)霞,王奎*,等.miRNA-200a調(diào)控淋巴瘤細(xì)胞增殖遷移的機(jī)制,中國(guó)老年學(xué)雜志,2020,40(12):2613-2616.

14.農(nóng)衛(wèi)霞,王奎*,等.LncRNA MALAT-1對(duì)彌漫性大B細(xì)胞淋巴瘤增殖和耐藥性的影響,中國(guó)免疫學(xué)雜志,2020,36(14): 1710-1719.

15.Wen Jie Zhang, Feng Li, Lin Tao, Kui Wang*. In Reply: Cervical screening by Pap test and visual inspection enabling same-day biopsy in low-resource, high-risk communities[J].Obstetrics&Gynecology,2019,133(3),584585.

16.孫倩,井明霞,王奎*,宋艷芳.兩種常用老年高血壓患者服藥依從性自我報(bào)告問(wèn)卷適用性分析[J].中國(guó)公共衛(wèi)生雜志,2019.（ISSN：1001-0580）

17.王奎*,芮東升,張眉,等.《衛(wèi)生統(tǒng)計(jì)學(xué)》實(shí)驗(yàn)課混合式教學(xué)改革實(shí)踐.農(nóng)墾醫(yī)學(xué), 2018,40（4）, 369-371.

18.Western environment/lifestyle has increased global genome methylation and decreased global gene expression in chinese immigrants living in australia，Environmental and Molecular Mutagenesis，2016，57：65-73.

19.Association of Insulin Resistance with Glucose and Lipid Metabolism: Ethnic Heterogeneity in Far Western China. Mediators of Inflammation 2016(3):1-8.

20.Association of APOA1 gene polymorphisms (rs670, rs5069, and rs2070665) with dyslipidemia in the Kazakhs of Xinjiang. Genetics and molecular research:GMR 2016,15(2). DOI: 10.4238/gmr.15028094.

21.Prevalence of Hypertension among Adults in Remote Rural Areas of Xinjiang, China. International Journal of Environmental Research and Public Health,2016, 13(6):524. DOI: 10.3390/ijerph13060524.

22.Comparison of Anthropometric and Atherogenic Indices as Screening Tools of Metabolic Syndrome in the Kazakh Adult Population in Xinjiang. International Journal of Environmental Research and Public Health 13(4):428, 2016. DOI: 10.3390/ijerph13040428.

23.Visceral Adiposity and Anthropometric Indicators as Screening Tools of Metabolic Syndrome among Low Income Rural Adults in Xinjiang. Scientific Reports, 2016, 6:36091. doi:10.1038/srep36091.

24.Standardizing Flow Cytometry ImmunophenotypingAnalysis from the Human ImmunoPhenotyping Consortium. Scientific Reports. 6:20686. DOI:10.1038/srep20686.

25.A benchmark for evaluation of algorithms for identification of cellular correlates of clinical outcomes. Cytometry: Part A. 89:16-21. doi:10.1002 /cyto.a.22732.

26.Inference on differential expression using cluster-specific contrasts of mixed effects. Biostatistics 16, 98-112.

27.Lutein alleviates arsenic-induced reproductive toxicityin male mice via Nrf2 signaling. Human & Experimental Toxicology 35(5), 2015. DOI:10.1177/0960327115595682.

28.Association between polymorphisms of fat mass and obesity-associated gene and metabolic syndrome in Kazakh adults of Xinjiang, China. Genetics and molecular research: GMR 14(4):14597-14606, 2015. DOI: 10.4238/2015.November.18.23.

29.Association between Eight Functional Polymorphisms and Haplotypes in the Cholesterol Ester Transfer Protein (CETP) Gene and Dyslipidemia in National Minority Adults in the Far West Region of China. International Journal of Environmental Research and Public Health 12(12):15979-15992, 2015. DOI: 10.3390/ijerph121215036.

30.Association of Inflammation with Metabolic Syndrome among Low-Income Rural Kazakh and Uyghur Adults in Far Western China. Mediators of Inflammation.  http://dx.doi.org/10.1155/2015/706768.

31.Joint modeling and registration of cell populations in cohorts of high-dimensional flow cytometric data，PLos One, 2014,9(7):e100334-e100334.

32.Critical assessment of automated flow cytometry data analysis techniques，Nature Methods，2013，10（3）：228-238.

33.Critical assessment of automated flow cytometry data analysis techniques, Nature Methods, 2013,10(3):228-238.

34.Autoantibody profiling to identify biomarkers of key pathogenic pathways in mucinous ovarian cancer，European Journal of Cancer,2010,46(1):170-179.

35.Automated high-dimensional flow cytometric data analysis，Proceedings of the National Academy of Sciences of the United States of America，2009，106（21）：8519-8524.

36.The effectiveness of a physical activity intervention for seniors，American Journal of Health Promotion，2008，22（5）：318-321.

37.Large-scale simultaneous inference with applications to the detection of differential expression with microarray data，Statistica，2008，68：1-30.

38.Contribution to the discussion ofthe paper by F. Chiaromonte and S. Tyekucheva, Test, 2008,17:43-46.

39.Reducing attrition in physical activity programs for older adults, Journal of Aging and Physical Activity, 2007,15(2):152-165.

40.Modelling bivariate count series with excess zeros, Mathematical Biosciences, 2005,196(2):226-237.

41.Recurrent ischemic stroke hospitalisation: A retrospective cohort study using Western Australia linked patient records, European Journal of Epidemiology, 2004,19(11):999-1003.

42.Recurrent gastroenteritis among infants in WesternAustralia: A seven-year hospital-based cohort study, Annals of Epidemiology, 2004,14(2):137-142.

承擔(dān)教學(xué)：承擔(dān)本科生《醫(yī)學(xué)統(tǒng)計(jì)學(xué)》《衛(wèi)生統(tǒng)計(jì)學(xué)》等課程的教學(xué)，留學(xué)生《Medical Statis》課程的教學(xué)，研究生《醫(yī)學(xué)統(tǒng)計(jì)學(xué)》、統(tǒng)計(jì)軟件和R語(yǔ)言及其在公共衛(wèi)生領(lǐng)域的應(yīng)用等課程的教學(xué)。